Achuthanandan's demand came in the wake of the agency registering a case against Congress leaders Ashok Gehlot, Sachin Pilot, Karthi Chidambaram and Ravi Krishna, sons of former Union ministers P Chidambaram and Vayalar Ravi respectively, in the controversial ambulance scam in Rajasthan.
"As the Rajasthan government has ordered a CBI probe into a similar corruption case there, such an inquiry has become relevant in Kerala also," the Marxist veteran said in a statement here.
"Allegations had been raised against the same company in Kerala also in connection with the 108 ambulance project," he said.
Besides the sons of former Union ministers, Chief Minister Oommen Chandy's former financial advisor Shafi Mehtar had also come under criticism in the issue in the state, he said.
The nonagenarian leader alleged that attempts were on to sabotage the case in Kerala as it had got inter-state ramifications and those involved are politically and financially influential.