"We demand Pradhan's resignation if the statement of Vyapam scam main accused Sudhir Sharma's IT returns for 2013 comes true," BJD spokesman P K Deb told reporters here.
Pradhan should cooperate with the CBI investigation into the scam after stepping down from the Union ministry if there is truth in the charge, he said.
Pradhan, however, denied the allegation of receiving payments from any accused of Vyapam scam.
BJD in a statement here also criticised the BJP-led NDA government at the Centre over charges being levelled against Union Minister Sushma Swaraj, Rajasthan Chief Minister Vasundhara Raje, Maharastra Minister Pankaja Munde and MP chief minister Shivraj Singh Chouhan.