He passed away yesterday night, Lebanon's NNA said.
"He was with his son in Mansouriya (near Beirut) when he began to feel unwell... He was immediately taken to hospital, where he died," NNA said.
Safi was often referred to as the "voice of Lebanon" and belonged to a golden age for music in his country and the wider Arab world, along with Lebanese diva Fairuz.
He held Lebanese, French and Brazilian nationality, and contributed to the revitalisation of Lebanon's music, a movement led by the Rahbani brothers.
With a catalogue of some 3,000 songs, Safi was best known for popular and folk themes in his music, but also sang Lebanese and Arabic poetry.
He was married with four sons and two daughters.