Spiegel died May 9 in Montreal, where he had spent the past four years in a nursing home, his son Julius Spiegel said Tuesday.
With Spiegel's death, the tiny group of survivors of the legendary World War II revolt that was crushed 70 years ago this month grows even smaller.
Spiegel was one of about 750 Jewish fighters who on April 19, 1943, launched an uprising that took the Germans off guard.
Ultimately, though, the Nazi revenge was brutal and involved burning the Warsaw ghetto down building by building.
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Only a few dozen of the Jewish fighters survived by escaping the ghetto through underground sewage canals to reach the so-called "Aryan side" of the Polish capital. Spiegel and his future wife Chaika Belchatowska were among them.
"He was essentially an ordinary guy forced by circumstances to do things that were out of character," Julius Spiegel told The Associated Press.
It's not clear how many of the fighters are still living, but the number is certainly tiny.
When Poland held national ceremonies last month marking the 70th anniversary of the start of the ghetto uprising, officials in Warsaw said they believed there could be four survivors left.
Only one, Simha Rotem, was visibly present at the ceremony, giving a speech and accepting a high state honor from the Polish president.