Bedene's remarkable run in the tournament ended with a tame 3-6 4-6 defeat against Wawrinka, who emerged as a new force in world tennis in 2014.
However, the Slovenian is taking a bagful of cherishable memories from the event, having recorded wins over top-20 players en route to the final.
Wawrinka did not face a single break point on his serve and needed only 90 minutes to grab his third Chennai Open title, having won it last year and also in 2011.
"It's special to start the year with a trophy. It's going to be a a strange feeling going to Australian Open as defending champion. First I want to enjoy this trophy. Happy to do it here again," Wawrinka said after the match.
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"It's amazing atmosphere. That's the reason why I keep coming back. It's a pleasure to play here, it's seven years now," the Swiss added.
Wawrinka had words of praise for his opponent too.
Bedene was elated at his performance in the last 10 days, becoming the first qualifier to reach final at Chennai Open.
"It's been a great week. Thank you everyone. I guess hard work pays off. Thank you my team, you were great. It's my favourite tournament now and I want to come back next year," Bedene said.