The West Indies Cricket Board said "differences in culture and strategic approach" were behind the decision to terminate Simmons' contract after 18 months in charge.
Simmons was briefly suspended last September for questioning the country's selection policy, after Dwayne Bravo and Kieron Pollard were omitted from West Indies' ODI squad for a series in Sri Lanka. Simmons was reinstated two months later after apologizing.
The WICB said it decided to separate from Simmons at a meeting of the board of directors on Saturday, "based on the public pronouncements of the coach and the approach internally."
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