"In the West they are trying to kick out Putin, to isolate him in international politics, to throttle Russia economically due to their interests, to bring down Putin," Kremlin spokesman Dmitry Peskov said.
"If it was not for Crimea, they would think up another reason," Peskov claimed in an interview with Argumenty i Fakty weekly.
He insisted that Russia's economic situation was under control despite "illegal sanctions" over its annexation of Crimea and support for separatist rebels in eastern Ukraine, which along with low oil prices have led to the ruble plunging in value.
Peskov said Russia could not resolve the crisis in Ukraine as the West demands.
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"Everything that Russia can do to end the conflict, it is already doing," Peskov said, pointing to humanitarian aid and supplies of coal and electricity.
"But Russia cannot resolve this conflict within Ukraine."
He said that Kiev needs "to start talking to its own regions."
"Germany, France, Russia and the OSCE can act as guarantors for a settlement," Peskov added.
Peskov conceded that despite euphoria over Crimea's annexation, Russia was in "an anxious state" due to "open confrontation from countries in the West -- an ideological, media, political and diplomatic (confrontation) but thank God not a military one."
"This confrontation makes us all expect a crisis," Peskov said.
The events in Ukraine "tore off the masks from international diplomacy," he added.
"By the way, Putin isn't expecting one," Peskov added.
"I'm sure the West will never get off our back," he said, adding that "isolationism would be a mistake.