The results of the referendum, which were confirmed as 51.9 per cent in favour of Brexit and 48.1 per cent against today, are not legally binding on the UK government.
However, the ruling Conservative party had promised the referendum as part of its manifesto pledge in the 2015 General Election and British Prime Minister David Cameron had repeatedly confirmed that the will of the people will be respected.
At a practical level, what this means is he has effectively kick-started a time-line for his own exit from Downing Street, expected by October, when a new Prime Minister will now have to take the Brexit mandate forward.
The most likely candidate is believed to be former London mayor Boris Johnson, who was the star campaigner for Vote Leave and often touted as Cameron's successor.
Also Read
Cameron will chair a Cabinet meeting on Monday and soon after travel to Brussels to inform the European Council of Britain's referendum next Tuesday and Wednesday.
The referendum has effectively triggered the process of a massive renegotiation process during which trade issues will be at the heart of talks to thrash out exactly how Britain's relationship with the EUwill work in future - negotiations that many expect will last for years.
Quitting the EU could cost Britain access to the EU's trade barrier-free single market and means it must seek new trade accords with countries around the world.
The EU, taken as a whole, is the UK's major trading partner, accounting for 44 per cent of exports and 53 per cent of imports of goods and services in 2015.
Officially, the process involves invoking Article 50 of the2009 Lisbon Treaty, which deals with the process of exit for any member country.
This will be the first time this article will be used, and indeed, tested as the only other country to exit the EU was Greenland back in 1982, when the EU was known as the European Economic Community (EEC).
Article 50 has provision for a two-year timeframe for negotiations, with scope to extend the negotiation period if all parties involved agree.
the way our people can travel, in the way our goods can move or the way our services can be sold".
However, his resignation and the need for a new Prime Minister to take charge of the negotiations has added a bigger question mark to the process ahead.
The European Commission has already indicated that it is not willing to wait for Britain to settle its own internal party politics to start the negotiation process.
In the interests of the EU's own future, European leaders are keen to conclude Brexit proceedings as quickly as possible to avert any further divisive referendums among its 27 other member-countries.
"The UK should invoke Article 50 as soon as possible, however painful that process may be,"said Jean-Claude Juncker, president of the European Commission, the executive branch of the EU.
He had warned before the vote: "Out is out".
On Saturday, the foreign ministers of the founding six member states - France, Germany, the Netherlands, Luxembourg, Italy and Belgium - will meet to discuss the implications of the British vote.
The deal the EU had struck with Cameron after months of negotiation earlier this year, has evaporated under a so-called "self-destruct" clause triggered by the referendum.
The terms of exit will be negotiated between EU's 27 counterparts, and each will have a veto over the conditions.
It will also be subject to ratification in national parliaments, which means MPs from individual member countries could squash aspects in their own Parliament.
Two vast negotiating teams will be created, with the EU side likely to be headed by one of the current commissioners and the British side most likely by a new Prime Minister.