The move comes amid pressure to stem abusive patent litigation from companies that do not sell products or services, but sue other companies to collect license of royalty fees.
A White House statement said President Barack Obama issued five executive orders and called for new legislation to update a reform enacted in 2011.
"Innovators continue to face challenges from patent assertion entities (PAEs), companies that, in the president's words 'don't actually produce anything themselves,' and instead develop a business model 'to essentially leverage and hijack somebody else's idea and see if they can extort some money out of them,'" the statement said.
The White House said new action is needed in the face of a flood of recent patent litigation, particularly in the smartphone sector, and because "several major companies spend more on patent litigation and defensive acquisition than on research and development."
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One of the signed orders calls for patent holders to by default have a "real party-in-interest" in a patent. This is aimed at creating more transparency to prevent the use of secretive "shell companies" holding patents.
The effort drew praise from TechAmerica, a major US technology lobby group.
"The strong support by the White House adds to the strong bipartisan support that reigning in abusive patent litigation shares," said TechAmerica's Kevin Richards.
"Protecting innovators intellectual property is a key component to maintaining the competitive advantage the United States has over the world.