The 57-year-old actress, who is currently the moderator and co-host on 'The View', would be lending her voice to White Rabbit's wife, reported Ace Showbiz.
Based around the fairytale novel of Lewis Carroll, 'Alice's Adventures in Wonderland', the story of 'Once Upon a Time in Wonderland' is a little different from other adaptations.
Goldberg's character would first appear in the eighth episode. It is not yet known if she will return in another episode.
The regular cast include John Lithgow, who voices White Rabbit, along with Sophie Lowe who stars as Alice, Emma Rigby as Red Queen, Naveen Andrews as Jafar and Michael Socha as The Knave of Hearts.