The big-bodied Wiese came in when Titans were tottering at 82 for five and then carried out a swift yet brutal assault smashing an unbeaten 61 off only 28 balls.
The pace trio of Mitchell Starc, Pat Cummins and Moises Henriques were left stunned by the Wiese carnage as he completed his 50 off 25 balls and hit five fours and four huge sixes. He changed his gears suddenly after playing 10 balls without a boundary. He hit the pull shots and straight over the long-on region with equal ease.
Along with opener Henry Davids who carried his bat through with an impressive 59 not out in 44 balls (3x4, 3x6), they added 81 runs in only 6.3 overs.
The last six overs produced a whopping 79 runs after the first 14 fetched them only 84 runs at the expense of five wickets.
Aussie pace sensation Cummins bowling figures went for a toss as he gave away 51 runs in his four overs. Henriques and Starc gave away 36 and 33 runs respectively and this happened solely due to Wiese.
Opting to bat, veteran batsman Jacques Rudolph slashed one hard from Josh Hazlewood but Michael Lumb stationed in the deep third man took a nice catch running to his left.
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Left-arm paceman Starc bowled a short one to Heino Kuhn who misread the length as he tried a pull shot but the ball clipped the off-bail.
Skipper Martin van Jaarsveld couldn't check his drive as he lobbed a simple catch to Cummins at cover to give Starc his second wicket.
At 36 for three, the home team was certainly in trouble but Davids took some calculated risks as he hit a few big hits during his 46-run fourth wicket partenrship with Farhan Behardien to stage a recovery. Once Behardien and Roloef van der Merwe were out in quick succession, Sixers thought of wrapping it up quickly but Wiese had other ideas.