Pep Guardiola's side have blown away any suggestion injuries and fatigue could derail their quest to win the Premier League, Champions League, League and FA Cup by scoring nine goals in their last two matches.
A 5-1 victory over Leicester last weekend extended City's lead at the top of the Premier League to 16 points, and that was followed on Tuesday with a 4-0 victory at Basel in the first leg of their Champions League last-16 tie.
Silva's substitute appearance was proof that he is over a hip problem, while England utility player Delph, a midfielder used largely as a left-back by his club this season, made his return after six matches out with a knee injury.
Sane's reappearance as a second-half substitute came well ahead of schedule as ankle ligament damage suffered in City's last FA Cup outing at Cardiff on January 28 was expected to keep the German out for six weeks.
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City can deliver the first trophy of Guardiola's reign in charge next Sunday against Arsenal in the League Cup final.
"Of course I am concerned because I saw the game against Bournemouth," Guardiola said. "Bournemouth are one of the teams I like to watch the most in the Premier League and Wigan were able to beat them.
"I think in the FA Cup there are a lot of surprises, not just this season or previous seasons, but all throughout history you always have these kind of situations happening.
"It would be good for my players not to think too much of the final next Sunday; they think about the final next Monday."
Paul Cook's side have led League One for most of the season, but ceded first place to Shrewsbury after successive defeats against Southend and Blackpool.
Wigan do pose an attacking threat, though, thanks to former Manchester United forward Nick Powell and Northern Ireland international Will Grigg, who have 27 goals between them this season. It was Grigg who scored twice as West Ham were beaten 2-0 in round four.
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