Trump gave few details but said he would expand on his plans at a major press conference on December 15 along with his children.
He has previously dismissed concerns over potential conflicts between his businesses and the presidency.
"I will be holding a major news conference in New York City with my children on December 15 to discuss the fact that I will leave my great business in total in order to fully focus on running the country to MAKE AMERICA GREAT AGAIN," Trump announced in a series of tweets.
His three eldest children already hold roles within the Trump empire which boasts golf clubs, office towers and other properties in several countries, including India.
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He has also previously suggested he could hand over his sprawling business interests to his three eldest children - Ivanka, Eric and Donald Jr, who already hold roles within his empire.
"While I am not mandated to do this under the law, I feel it is visually important as President, to in no way have a conflict of interest with my various businesses," he said in another tweet.
"The Presidency is far more important task," Trump said in another tweet trying to end the controversy surrounding the alleged conflict of interest he would have with his business while he is President of the US.
Trump, who was elected as the 45th president of the US on November 8, will be sworn in on January 20.
There is no legal requirement to liquidate assets but past US presidents have set aside their business deals. Trump's rivals have raised repeated concerns this may cause problems in the coming months.