"I'm going on a crucial and historic mission," Netanyahu said before his departure to the US from Ben-Gurion Airport.
"I feel I am the representative of all Israel, even those who disagree with me. I feel a deep concern for the fate of Israel. I will do everything to guarantee our future," the Israeli Premier, who is being accompanied by his wife on the trip, said.
The Israeli leader's speech to the US Congress, the invitation for which is said to have been obtained by manipulation behind US President Barack Obama's back, has sparked outrage both in Israel and America.
Critics in Israel have accused Netanyahu of trying to use the speech to bolster his own political chances in the March 17 Knesset elections where current opinion polls show the opposition gaining strength.
Also Read
The much publicised event has also caused controversy over the fact that the White House was apparently deliberately kept in the dark about the invitation to Netanyahu. The invitation was issued by Republican Speaker of the House John Boehner.
The speech will have a five-minute delay in transmission in Israel to allow any comments perceived by the Central Elections Committee as electioneering to be cut out.