"China will give you every support and assistance and by helping you, we have to help ourselves," Li said while addressing a special session of the Senate or Upper House of Pakistan's Parliament.
Pakistan's support is vital for China's development, he said, adding that both the countries should stand shoulder-to-shoulder as friends and brothers with "pragmatic cooperation".
Li, in his maiden visit to Pakistan as Chinese Premier, said China will extend further cooperation in all sectors, especially in the fields of strategic relations, energy, science and technology and agriculture.
Highlighting priorities for taking both countries towards development and progress, Li said they would have to speed up the development of the Karakorum Highway and its use for trade activities.
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"We are ready to work with Pakistan to speed up the project of upgrading the Karakoram Highway, actively explore and develop the long-term plans of building a China-Pakistan economic corridor, expanding our shared interests", he said.
Launching social and financial projects and cooperation in energy and agriculture would also boost bilateral ties, he said.
Referring to Pakistan's geo-political significance, Li said the country was involved in maintaining regional stability and global peace.
He said support and cooperation were vital for the mutual benefit of both countries.