But boxing -- perhaps more than any other sport -- is littered with men who proclaimed they were hanging up their gloves, only to find the lure of just one more shot at the big time or one last payday too much to resist.
The unbeaten Mayweather, 38, the self-proclaimed "TBE" ("The Best Ever"), insists he will not be joining them.
But then this is not the first time that he has said he is retiring: in 2008 he also said he was done.
"If you stick around anything too long, anything can happen. I'm not really worried about losing, but I want to have a sharp mind. You can make a lot of money, but you still want to be able to talk, walk, and have a sharp mind," he said.
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"Of course, it's always about self-preservation. I come first but I appreciate the fans. I do. The only thing I can do is believe in myself and believe in my skills. I'm going to be TBE until the day I die."
He also says that he has plenty to occupy him after he stops fighting: he is already a boxing promoter, has his own clothes line and says he wants to develop his interests in the entertainment and music industry.
Last week, Leonard Ellerbe, CEO of Mayweather Promotions, said there had been "signficant" entertainment possibilities for the champion for when he calls it quits -- including three "major" movie offers just last week.
"I've been approached on numerous occasions (to act) but I'd rather be behind the scenes. I've had my time to shine," said Mayweather, who has spent time in jail for one of a string of domestic violence incidents.