It was recently announced that work on a follow-up movie isn't happening right now, but the actress wouldn't be against the idea in the future, reported Collider.
Ryder, who played goth teen Lydia in the original, said: "I don't really know what's going on with that.
"Obviously, it was an iconic film. The only way it could really ever be done is with Tim (Burton) and Michael (Keaton). There's something that really resonates with all ages with that film. It's interesting. I think it would be great if it happened, if it was the right circumstances.
It's not the first time Ryder has spoken about the possibility of a sequel, after she sparked rumours of a new "Beetlejuice" movie last year during an appearance on "Late Night with Seth Meyers".
The much-loved cult classic starred Geena Davis and Alec Baldwin as Barbara and Adam Maitland, a married couple who die in a car accident and find themselves haunting the dream house they bought when alive.