Khalifa, who filed for divorce from the mother of his two-year-old son last September, said he is not interested in reworking on their marriage, reported Us magazine.
"No thanks," said Khalifa, when a fan tweeted him, "get your wife back."
"A woman who would do something to a kid to spite that kids father is a foul creature (sic)," he tweeted, before adding, "Seen my boy. All is well."
Without sharing any specifics, the 27-year-old rapper went on to explain, "That's pretty much the only thing that can spin my universe out of control... Sucks when people try to use that against you but the cool part is figuring out how much self control you have."
"As long as he's playing and smiling I'm cool..,," he tweeted.
The duo began dating in 2011 and got an engaged a year later. They wed in 2013.