In a case that has shocked the country, the four siblings -- ages four to 17 -- were each killed with a single bullet to the head in the town of Florencia, 370 kilometers south of Bogota.
Their parents had gone to enroll them in school, leaving them alone in the house. Their bodies were found on February 5.
A fifth boy, aged 12, was wounded but survived the shooting.
Prosecutors allege that Artunduaga planned the murders, apparently driven by a desire for revenge against the parents.
On Saturday, two men were arrested on suspicion of carrying out the actual killings, along with a brother of one of the two.
Colombia's public defender, who is tasked with protecting human rights, says 1,115 minors were murdered in the country in 2013, the latest year for which statistics are available.