Mary Ann Franco, gradually became blind after injuring her spine in a car accident in 1993.
Then, more than two decades later, another accident and a subsequent operation appears to have led to the recovery of her sight, although doctors are still trying to work out how exactly this could have happened.
"I was fully blind - all I could see was blackness," she told The Independent.
After the fall, which took place in August 2015, she was incapacitated and had to wear a neck brace until an operation a few weeks ago.
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She was in hospital recovering from four hours of surgery on her neck when she came round from the anesthetic and realised her sight had returned.
However, in her confused state, she did not realise what had happened straight away.
Neurosurgeon Dr John Afshar, who performed the operation, told ABC News that he had not expected Franco's vision to be affected.
"The restoration of Mary Ann Franco's vision is a true miracle," he said. "I really don't have a scientific explanation for it."
He said that one theory for the exceptional story was that the accident could have affected an artery and restricted blood flow to the part of the brain which controls vision.
Franco is a firm believer in God and attributes the extraordinary return of her sight to her faith.
She spoke of how happy she was to be able to see her family once again, and added that regaining her sight had changed how she thought of the world.
"Everything seems so much smaller to me, since I can see. I felt like the room was bigger than it was ... But they weren't as big as I thought," she said.