The 36-year-old woman had returned following a quarrel with her husband, a construction labourer at Chennai, some days ago.
She had allegedly given a poison-laced beverage to the children--two boys and girl-- last night and then consumed it herself, police said.
While the three children died on the spot, the woman passed away at the Government Hospital here, police said.
Police said a case was registered following a complaint from her father.