The "Heroes" singer, who starred in several films, had a cameo in the comedy movie when he judges a catwalk battle between Stiller's Derek Zoolander and Owen Wilson's Hansel McDonald.
Stiller said he still can't believe Bowie agreed to appear in the 2001 movie and the actor was "devastated" when he learned the news the musician had passed away last month from cancer at the age of 69, reported Female First.
"He was a huge influence on so many people, I think on our culture, in the last 40 or 50 years, when you go back and look at how long he was making music, David was so ahead of the curve. I think I'm like everyone else, influenced by him in that way. It was really a high point in my career that he came down to spend time with us. Bowie is sadly missed, it is just terrible news."
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The 50-year-old actor can even recall the rocker even added some of his own lines to the part.
"Oh, it would have been great to have him in the second one ... But having him in the first was a very special thing, and I will always cherish that. David had a great sense of humour. He got what the joke was and he had fun playing around with it... He even came up with a bit of writing on his hand and he was a very good actor as we all know."