Despite the problems of mass species extinction, global warming and the threat of artificial intelligence, Hawking remains optimistic about the future of humanity.
He said that he looked back on his life with gratitude and towards the years to come with cautious hope.
However, he is worried that humans may not have the skills as a species to stay alive.
"We need to be quicker to identify such threats and act before they get out of control. This might mean some form of world government. But that might become a tyranny," said Hawking.
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"All this may sound a bit doom-laden but I am an optimist. I think the human race will rise to meet these challenges," he said.
"Since civilisation began, aggression has been useful in as much as it has definite survival advantages," he said.
"It is hard-wired into our genes by Darwinian evolution. Now, however, technology has advanced at such a pace that this aggression may destroy us all by nuclear or biological war," he added.
He argued that there were new challenges too - among them environmental problems and his concern that artificial intelligence could supplant humans.
Hawking had earlier warned that the creation of powerful artificial intelligence may turn out to be "the worst thing ever to happen to humanity" despite its potential benefits.