The scroll is among hundreds retrieved from the remains of a lavish villa at Herculaneum, which along with Pompeii was one of several Roman towns that were destroyed when Mt. Vesuvius erupted in AD 79.
Some of the texts from what is called the Villa of the Papyri have been deciphered since they were discovered in the 1750s.
But many more remain a mystery to science because they were so badly damaged that unrolling the papyrus they were written on would have destroyed them completely.
Previous attempts to peer inside the scrolls failed to yield any readable texts because the ink used in ancient times was made from a mixture of charcoal and gum. This makes it indistinguishable from the burned papyrus.
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Mocella and his colleagues decided to try a method called X-ray phase contrast tomography that had previously been used to examine fossils without damaging them.
Phase contrast tomography takes advantage of subtle differences in the way radiation such as X-rays passes through different substances, in this case papyrus and ink. Using lab time at the European Synchrotron Radiation Facility in Grenoble, France, the researchers found they were able to decipher several letters, proving that the method could be used to read what's hidden inside the scrolls.
The next challenge will be to automate the laborious process of scanning the charred lumps of papyrus and deciphering the texts inside them, so that some 700 further scrolls stored in Naples can be read, Mocella said.
Scholars studying the Herculaneum texts say the new technique, which was detailed in an article published Tuesday in the journal Nature Communications, may well mark a breakthrough for their efforts to unlock the ancient philosophical ideas hidden from view for almost two millennia.