Washington has sharply intensified its air war against the jihadists since President Donald Trump took office in January.
One strike hit a vehicle in the southern province of Shabwa, killing two suspected militants, the sources said.
A second hit a car in Marib province, east of the rebel- held capital Sanaa, killing three, they added.
Both Shabwa and Marib are largely held by Saudi-backed government forces but Al-Qaeda has taken advantage of fighting between them and the rebels to step up its presence.
Washington regards Al-Qaeda's Yemen-based branch as its most dangerous and accuses it of plotting multiple attacks against the West.
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