However, men did not appear to benefit the way women did, raising questions about why a heart healthy diet may benefit one sex over the other, according to the study presented at the American College of Cardiology conference.
The research was based on 2,508 participants in the government-sponsored Coronary Artery Risk Development in Young Adults (CARDIA) study, which began in the 1980s with the aim of tracking heart health among 18-30 year olds over time.
The association remained even after researchers accounted for other lifestyle behaviors that could impact cardiovascular health.
"These findings confirm the concept that plaque development is a lifelong process, and that process can be slowed down with a healthy diet at a young age," said lead author Michael Miedema, a cardiologist at the Minneapolis Heart Institute.
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Researchers are not sure why the same benefits were not apparent in men, and said one possibility is that not enough men were included in the study to provide a clear picture.
Sixty-three percent of the people in the study were female and 37 percent were male.
"Several other studies have also suggested that a diet high in fruits and vegetables is less protective in men, but we do not have a good biological reason for this lack of association," Miedema said.