The 30-year-old big-hitting batsman had got engaged in a private ceremony at his farmhouse in Nadiad, 60 kms from Vadodara, last year.
Afreen was born and brought up in Mumbai but practises physiotherapy in Vadodara.
It is an arranged marriage and the match was decided after both families gave their consent.
Pathan, who has been out of the Indian team for some time now, has scored 1365 runs in 57 ODIs and 438 runs in 22 T20s.