Khan, who missed three matches due to a hamstring injury, took back the reins of the side from Karun Nair. Shahbaz Nadeem made way for the captain.
Daredevils have replaced Chris Morris with Marlon Samuels while Mumbai have brought in Lendl Simmons for Jos Buttler and left out Krunal Pandya to include Harbhajan Singh.
Teams:
Mumbai Indians: Rohit Sharma (C), Parthiv Patel, Lendl Simmons, Nitish Rana, Keiron Pollard, Hardik Pandya, Karn Sharma, Harbhajan Singh, Mitchell McClenaghan, Jasprit Bumrah and Lasith Malinga.