The denial came after local media and online outlets reported that he married Tanvir Zamani, a US-based doctor.
59-year-old Zardari's spokesman Farhatullah Babar in a statement rejected the reports and said that ex-president will live and die as "spouse of Benazir Bhutto".
Babar said that for the past several days one Tanvir Zamani has been appearing almost regularly on the television channels masquerading as a Pakistan People's Party (PPP) leader and at times even as a spokesperson of the party.
"The rumours of Mr Zardari having married this lady have unfortunately been deliberately aided by the said lady by avoiding answers to pointed questions, speaking with double tongue and otherwise employing gestures and pauses in replies to the questions," the spokesperson said.
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He said the rumours about Zardari's marriage were first floated in 2011 when he was president and were rejected at that time.
"Mr Asif Zardari has the unique honour of being the spouse of Shaheed Benazir Bhutto and son in law of Shaheed Zulfikar Ali Bhutto. He regards this an honour for which he has endured all sorts of vicious attacks and even jeers and ridicule," Babar said.
Babar said any impression that the said lady is some sort of a leader of the PPP is totally wrong.
The spokesperson also deplored that some channels and anchor persons gave so much of airtime to show so much of nonsense in the craze for ratings even when the charade was obvious.