But the result of the party's other leadership races will mean that even if Ramaphosa becomes president in 2019, he will have to share power with the party faction that opposed his leadership bid.
And in the meantime, President Jacob Zuma remains head of state, limiting Ramaphosa's room for manoeuver.
Even though Zuma and Ramaphosa presented an amiable front to the world during the conference, relations between the two remain badly strained.
His criticism of alleged official misconduct were seen as attacks on the legacy of Zuma, who has been embroiled in dozens of corruption and cash-for-access scandals.
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It also helped to undermine his rival for the party leadership, Nkosazana Dlamini-Zuma, by raising fears that as Zuma's ex-wife she might seek to shield him from prosecution.
Images of her disconsolate reaction to Ramaphosa's victory quickly went viral online.
"(Leaders') actions should always be a source of pride, and not a cause for embarrassment," he said.
If the ANC has a hope of keeping its absolute majority in general elections due in two years, Ramaphosa will quickly need to address the Zuma situation.
"Given the negative image of the president and the looming 2019 elections, he will have to distance himself," said Victor Magnani, an Africa specialist at the French Institute of International Relations (IFRI).
Zuma's second term leading South Africa concludes in mid-2019.
Despite the numerous legal scandals dogging him, Zuma has until now always survived no-confidence votes, protected by the ANC's large parliamentary majority.
Which leaves the option of resignation. A precedent exists: in 2008 Zuma successfully forced his predecessor Thabo Mbeki to cut short his term by eight months after assuming the party leadership.
This scenario has gained traction in some corners of the ANC in recent days.
Fikile Mbalula, the police minister and a Dlamini-Zuma supporter, told the media that any such tensions would be handled by the party's National Executive Committee (NEC).
"The ANC takes decisions and its deployees in government must abide," he said referring to party members appointed to jobs in the executive.
But in the election of NEC members yesterday, three posts went to Dlamini-Zuma loyalists - seen as favourable to Zuma himself - and three to Ramaphosa's camp, including the party leader himself.
Even before the end of the conference, backers of the new leader had already begun a campaign to ease Zuma towards the exit.
In its final resolutions, the party agreed to quickly put in place a commission of judicial inquiry to investigate high-level corruption.
The move was a major snub to Zuma, who has stalled for months over demands that he open an inquiry into his ties with the influential Gupta business family, which is accused of influence peddling and misappropriation of public funds with Zuma's blessing.
Zuma suggested that he would appeal the court ruling, a move which some in the ANC would probably consider sufficiently serious defiance to justify a recall or vote of no confidence.