MSCI's broadest index of Asia-Pacific shares outside Japan lost over 1%, while Tokyo's Nikkei dropped 2.4% to an eight-week closing low.
Spot gold rose to a session-high of $1,227.60 an ounce before paring some gains to trade up 0.9% at $1,225.35 by 0644 GMT. It had dropped 1.4% in the past two sessions.
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"We are getting mixed data out of the US and somewhat-contradictory comments from the Fed. That is creating some uncertainty for gold," said a Singapore-based trader, adding that the metal was seeing some technical support near its 50-day moving average near $1,215 an ounce.
US data on Monday showed that new orders for manufactured goods dropped in February, while business spending on capital goods was much weaker than initially believed.
This follows a robust US jobs report last week that showed non-farm payrolls rising by a better-than-expected 215,000, stoking speculation that the Fed could raise rates soon.
Gold had posted its biggest quarterly rise in nearly 30 years in the March quarter, rallying 16% as expectations faded that the Fed would move to normalize interest rates due to concerns over the global economy.
The US central bank raised rates in December for the first time in nearly a decade.
Fed Chair Janet Yellen said last week that the US central bank would proceed cautiously with rate increases.
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But Boston Federal Reserve President Eric Rosengren said on Monday it was "surprising" that futures markets currently imply only one or no interest rate hikes this year, a prediction he said could prove "too pessimistic".
The metal is highly exposed to rising rates, which lift the opportunity cost of holding non-yielding assets, while boosting the dollar.
Analysts warned that gold prices could be undermined by outflows from bullion funds and soft physical demand.
Assets of SPDR Gold Trust, the top gold-backed exchange-traded fund, fell 0.29% to 815.72 tonnes on Monday. Last week, the fund experienced its first net weekly outflow this year, after climbing to its highest in over two years in March.
Elsewhere, India's gold imports in February fell 34%, news agency NewsRise Financial reported on Monday, citing a government official.
"The physical market remains weak, with India trading at a discount and a modest response from China, and in our view, the current floor looks to be soft, implying better entry levels could be in the offing," Standard Chartered said in a note.