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Cipla to collaborate with US-based MEDRx for muscle relaxant drug

As per the deal, MEDRx to receive upfront payment of about $ 30 mn & will be eligible for royalties

Cipla's Goa plant
BS B2B Bureau Mumbai
Last Updated : Apr 07 2017 | 3:14 PM IST
Cipla USA Inc, the wholly-owned subsidiary of the Mumbai-based pharmaceutical company Cipla, has signed a worldwide licensing agreement (except for East Asia) with MEDRx Company Limited (MEDRx) to further develop and commercialise MRX-4TZT, a tizanidine patch for the management of Spasticity. Tizanidine is a type of central analgesic (acts on the central nerves in the brain and the spinal cord to relieve muscle tonicity). This drug is used to alleviate discomfort from shoulder stiffness, back problems, frozen shoulder, tension headaches and other problems.

Under the terms of the agreement, MEDRx is eligible to receive up to $ 30 million cumulatively through upfront and developmental, regulatory, and commercial milestones payments. MEDRx will also receive tiered royalties on the net sales of commercialised licensed products.

MRX-4TZT is a medicated patch that uses ILTS (ionic liquid transdermal system), an exclusive MEDRx technology that incorporates its ionic liquid expertise, to deliver tizanidine (a centrally acting muscle relaxant). MEDRx has concluded phase I trials in US with a promising horizon for further clinical development. Annual sales of muscle relaxants in the US was estimated at approximately $ 807 million in 2016. MRX-4TZT is expected to be the first transdermal muscle relaxant worldwide. 

Delivering tizanidine by transdermal administration, rather than by oral administration, is expected to improve patient experience on the drug by providing sustained efficacy while also reducing adverse events and side effects such as aesthenia, troublesome drowsiness and dry mouth amongst others. Cipla plans to initiate phase 3 clinical trials after completion of additional phase 1 studies.

After bolstering its US generics business through two acquisitions last year, Cipla is now actively foraying into the US branded specialty space through a blend of in-house innovation and inorganic efforts. Umang Vohra, managing director and global CEO Cipla Ltd, opined,  “In-line with our legacy and philosophy of keeping the patient at the centre, we believe that the tizanidine transdermal patch will address significant unmet needs and benefit patients globally suffering from chronic Spasticity.”
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