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How early childhood adversities leave behind impacts, reflected as bodily changes in adolescence, in turn influencing their physical and mental health throughout life, has been uncovered in a new study published in The Lancet Child & Adolescent Health. Researchers at Massachusetts General Hospital (MGH), Boston, US, involved in this study, had previously showed that exposure to adversity between ages 3 and 5 significantly affected the epigenome of children at age 7, altering biological processes possibly linked to damaging long-term health outcomes. "We wanted to determine if the epigenetic profiles associated with adversity that we observed in children at age 7 persisted into adolescence and whether the timing of exposure to adversity influenced epigenetic trajectories across development," said first author Alexandre A. Lussier, research fellow at MGH. Epigenetics is the study of stable changes or mechanisms in cell function not involving DNA alterations, one such mechanism being