A shipment of medicine for dozens of hostages held by Hamas was en route to Gaza on Wednesday after France and Qatar mediated the first agreement between Israel and the militant group since a weeklong cease-fire broke down in November.
The medicines will be shipped through Egypt and delivered to the International Committee of the Red Cross, which will then hand them over to Hamas. Qatar said the deal also includes the delivery of additional medicine and humanitarian aid to Palestinians in the besieged coastal enclave.
The deal came more than 100 days into a conflict that shows no sign of ending and which has sparked tensions across the Middle East, with a dizzying array of strikes and counterstrikes in recent days from northern Iraq to the Red Sea and from southern Lebanon to Pakistan.
In Gaza, Palestinian militants are still putting up resistance across the narrow coastal strip in the face of one of the deadliest military campaigns in recent history. Some 85 per cent of the territory's population of 2.3 million people have fled their homes and the UN says a quarter of the population is starving.
Israel has vowed to dismantle Hamas' military and governing abilities to ensure that it can never repeat the October 7 attack that triggered the war. Militants burst through Israel's border defences and stormed through several communities, killing some 1,200 people, mostly civilians, and capturing around 250.
Israel has also vowed to return the more than 100 hostages still held inside Gaza after Hamas released most of the rest in November in exchange for Palestinians imprisoned in Israel. Israel says only military pressure will bring about the release of more captives, but as the fighting grinds on they are at increased risk of being killed in Israeli strikes or during rescue operations.
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Hamas has said it will not release any more hostages until there is a permanent cease-fire, something Israel and the US, its top ally, have ruled out.
In just the last few days, a US-led coalition has carried out strikes against Iran-backed Houthi rebels in Yemen, Iran has struck what it described as an Israeli spy headquarters in northern Iraq and militant bases in Pakistan and Syria, and Israel and Lebanon's Hezbollah have escalated the intensity of their fighting across the border.
Iran-backed militant groups across the region say they are striking US and Israeli targets to pressure them to halt the Gaza offensive. Iran itself has encouraged the attacks while avoiding direct involvement, but appeared to be flexing its muscles with the strikes in Syria and Pakistan.
The Houthis have vowed to continue attacking international shipping in the Red Sea in what they say is a blockade of Israel, with repercussions for global trade.
Each party appears to be seeking some form of deterrence against its adversaries, but the longer the war in Gaza lasts, the more likely it is that one of them goes a step too far, potentially triggering another war.
The biggest risk is in Lebanon, where Israel has vowed to halt Hezbollah attacks so that tens of thousands of Israelis can return to their homes in communities evacuated in October. Hezbollah hopes to take the pressure off Gaza by tying down Israeli troops in the north.
Tensions are also soaring in the occupied West Bank, where Israeli forces have conducted near-daily arrest raids that often trigger shootouts with Palestinian militants. Israel said Wednesday that an airstrike in the urban Balata refugee camp in the northern West Bank killed a senior militant implicated in recent attacks on Israelis. Over 350 Palestinians have been killed in the West Bank since October 7.
Israel said at the start of the year that it had largely dismantled Hamas in northern Gaza and would scale back operations there, focusing on dense urban areas in the center and south of the territory. But there has been little apparent letup in strikes, with scores of Palestinians killed every day.
Gaza's Health Ministry says 24,285 Palestinians have been killed since the start of the war. The ministry does not differentiate between civilian and combatant deaths but says around two-thirds of those killed were women and children. Over 60,000 people have been wounded, and less than half of Gaza's hospitals are even partially functioning.
Israel blames the high civilian death toll on Hamas because it fights in dense residential areas. Israel says its forces have killed roughly 9,000 militants, without providing evidence, and that 190 of its own soldiers have been killed in the Gaza offensive.
Palestinian militants are still fighting in all parts of the territory, and Israel appears no closer to freeing the scores of hostages still held by Hamas. Two hostages' deaths were confirmed on Tuesday after Hamas said they were killed in Israeli airstrikes.
France said it took months to organize the shipment of the medicines. Qatar, which has long served as a mediator with Hamas, helped broker the deal, which will provide three months' worth of medication for chronic illnesses for 45 of the hostages as well as other medicine and vitamins.
Several elderly men are among the remaining hostages held by Hamas after most women and children were released in November.
Qatar said the deal includes the provision of additional humanitarian aid to Gaza, without elaborating.
Senior UN officials have warned that Gaza faces widespread famine and disease if more aid is not allowed in.
Israel completely sealed off Gaza after Hamas' October attack and only relented under US pressure. It says there are now no limits on the entry of humanitarian aid and that U.N. agencies could reduce the delays by providing more workers and trucks.
But UN officials say aid delivery is hobbled by the opening of too few border crossings, a slow vetting process, and continuing fighting throughout the territory all of which is largely under Israel's control.