A study of 614 fully vaccinated health workers in India found a "significant" drop in their Covid-fighting antibodies within four months of the first shot.
The findings could help the government decide whether to provide booster doses as some western countries have done.
Waning antibodies do not necessarily mean that immunised people lose their ability to counter the disease, as the body's memory cells may still kick in to offer substantial protection, said the director of a state-run institute that did the study.
"After six months, we should be able to tell you more clearly whether and when a booster
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