Retinoids are chemicals whose effect on the skin is similar to that of vitamin A (retinol). They may be obtained naturally or created synthetically. The outermost layer of the skin, called the epidermis, consists of a top layer of dead cells that act as a barrier to microorganisms and the environment and help in water retention. The top layer is a dynamic structure that also contains melanocytes, responsible for skin pigmentation, and Langerhans’ cells, which drive the skin’s immune response system against infections. Retinoids help to loosen or separate this top layer of the epidermis (the horny layer of the