"It was a suicide car bomb in front of the Indian embassy. There are casualties but at this time we don't have a figure," ministry spokesman Zemarai Bashary said.
An Afghan man at the scene told AFP it appeared that the bomber blew up just outside the gate of the embassy, which is near the interior ministry.
About four cars were destroyed and flesh was scattered across the area, but it was not clear if it was from the bomber or casualties, he said.