The rupee is trading lower at 63.44/45 vs Tuesday's close of 63.28/29.
The dollar index is trading above the key 90 level for the first time since March 2006 after strong US and UK economic data.
RBI intervention is seen at 63.50/55 levels, traders say.
Month-end dollar demand from oil companies is also hurting the Indian unit.
The pair is seen in 63.20 to 63.60 range during the day.