Standard Chartered is in talks with regulators about making Frankfurt its European base to secure market access to the European Union when Britain leaves the bloc.
"We are looking at setting up a subsidiary in the EU to ensure we are prepared," Chairman Jose Vinals said on Wednesday at the Asia-focused bank's annual shareholder meeting in London.
"The choice of Frankfurt is very natural as we have a branch there and we do euro clearing there," he said.
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Financial services firms need a regulated subsidiary in an EU country to offer their products across the bloc if Britain no longer has access to the European single market.
Bankers say Frankfurt is set to win the most business following a discreet but concerted campaign to promote the financial centre of Europe's biggest economy.
Vinals, in his first appearance in front of shareholders since being appointed chairman, said Standard Chartered is unlikely to see a material impact from Brexit.
He said the board had decided it was the bank's best interest not to declare an ordinary dividend for 2016, but said it is committed to resuming dividends as soon as possible.
The bank halted its dividend in 2015 to bolster its balance sheet, under a plan to restore profitability after three years of falling profit and strategic missteps.