The Dow ended down just a fraction of a point, within about 4 points of its record closing high of 16,576.66 set on December 31. The Dow posted an all-time intraday high during the session.
Market outperformers in the Internet and biotech sectors lost ground, resuming a selloff from March after some recent gains. Two weeks ago, biotechs suffered their worst day since 2011.
"That's a buying opportunity in our view. We think (biotech) will come roaring back. It's not just going to have one good year and be done," said Randy Warren, chief investment officer of Warren Financial Service in Exton, Pennsylvania.
The Nasdaq biotechnology index slid 2.7%.
Among momentum stocks, the shares of Tesla Motors
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Investors were reluctant to make big bets ahead of Friday's nonfarm payrolls report, when they will be looking for evidence that recent weather-related weakness in the economy has passed. Economists expect that employers added 200,000 jobs to nonfarm payrolls in March, according to a Reuters poll.
The Dow Jones industrial average dipped 0.45 of a point to close at 16,572.55, after hitting an intraday record of 16,604.15.
The S&P 500 slipped 2.13 points or 0.11%, to finish at 1,888.77. It also hit an intraday record high of 1,893.80. The Nasdaq Composite dropped 38.716 points or 0.91%, to end at 4,237.74.
The Global X Social Media ETF
Some analysts said the selloff in "momentum" stocks has yet to run its course
The options market also focused on momentum stocks, with Tesla Motors remaining a favorite with the speculative crowd for a second day. The total option volume by afternoon was running at about a 30% mark-up to what's typically seen.
Anadarko Petroleum Corp
Shares of Barnes & Noble Inc
The S&P 500 now consists of 501 stocks, with the index including both Google Inc's Class A
On the economic front, the US trade deficit unexpectedly widened in February to $42.3 billion as exports hit a five-month low, suggesting that first-quarter growth could be much weaker than initially expected.
A bright spot came from the services sector, where growth accelerated in March after being hampered by unusually cold weather, according to the Institute for Supply Management's services-sector index.
In the biopharmaceutical sector, Gilead Sciences Inc
About 6.0 billion shares changed hands on US exchanges, below the 6.4 billion average so far this month, according to data from BATS Global Markets.
Decliners beat advancers on the New York Stock Exchange by 1,772 to 1,220 and on the Nasdaq by 1,837 to 775.