Polling stations across the United Kingdom opened on Thursday morning to decide the historic referendum on whether the country should remain a member of the European Union or leave the politico-economic union of 28 member states.
The voting will place between 7 a.m. and 10 p.m. local time.
The national referendum is the third in the UK history and comes four months after battle for votes between the Leave and Remain campaigns.
Prime Minister David Cameron criss-crossed the country in a final effort to warn Britain's voters against rejecting the EU in the historic poll yesterday.
This decision will also read as a referendum on his premiership.
Last night, he was joined by former prime ministers Gordon Brown and Sir John Major, the Liberal Democrat leader, Tim Farron, and the Green MP Caroline Lucas, at events in Bristol and Birmingham, reports the Guardian.
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The prime minister has been pressing the message that today's decision will be irreversible and there will no coming back if the UK votes to leave the EU.
Cameron will vote in his Witney constituency before returning to 10, Downing Street to watch the results come in overnight.
Once the result emerges, Cameron is expected to make a statement before financial markets open on Friday morning.