Natalie Nougayrede, managing editor of French newspaper Le Monde has resigned amid a newsroom rebellion over the paper's future.
Nougayrede, the first woman to hold the post, said she had been "undermined" as head of the paper, the BBC reported.
Last week, most of Le Monde's chief editors stepped down after growing disputes over proposed changes.
Analysts say the press in France, as elsewhere, is struggling to maintain profit as the internet eats into readership and advertising.
News of her resignation came as the New York Times announced it had replaced the first woman to lead the paper - executive editor Jill Abramson - with immediate effect.
In a letter, Nougayrede said she no longer had the authority to do her job with the "peace of mind and serenity" necessary.