At least 350 people were killed in a massive landslide that buried a village in the north-east Afghan province of Badakhshan.
According to The BBC, hundreds of homes were buried under mud and rocks when a section of a mountain collapsed following torrential rain.
The rescue mission has begun to search for any survivors of the natural disaster.
Officials say that as many as 2,000 people are missing and dozens are trapped under rocks.
The UN mission in Afghanistan said in a statement that the number of deceased has increased to 350 and significant displacement is expected, adding that the UN Office for the Co-ordination of Humanitarian Affairs (OCHA) is helping local authorities to rescue those still trapped.
Heavy rains have been pouring in much of north and east Afghanistan in recent days, raising fears of subsequent landslides.
Some 150 people have reportedly died in flooding following heavy rains in the region.