A new study claims that it is possible to reverse brain damage which is caused by severe sleep apnea.
The neuroimaging study is the first to show that the white matter damage of obstructive sleep apnea patients could be upturned by continuous positive airway pressure therapy. The results underscore the importance of the "Stop the Snore" campaign of the National Healthy Sleep Awareness Project.
Results show that participants with severe, untreated sleep apnea had a significant reduction in white matter fiber integrity in multiple brain areas. The brain damage was accompanied by impairments to cognition, mood and daytime alertness. Although three months of CPAP therapy produced only limited improvements to damaged brain structures, 12 months of CPAP therapy led to an almost complete reversal of white matter abnormalities. Treatment also produced significant improvements in nearly all cognitive tests, mood, alertness and quality of life.
The study involved 17 men with severe, untreated obstructive sleep apnea who had an average age of 43 years. They were evaluated at baseline and after both three months and 12 months of treatment with CPAP therapy. At each time point they underwent a neuropsychological evaluation and a diffusion tensor imaging examination. DTI is a form of magnetic resonance imaging that measures the flow of water through brain tissue.
Participants were compared with 15 age-matched, healthy controls who were evaluated only at baseline.
The study results are published in the journal Sleep.
