Scientists have progressed in the search for the first broad-spectrum drugs to combat human rhinoviruses (HRVs), which cause the most common infectious diseases among humans.
Angus MacLeod and colleagues note that although many HRV infections cause mild disease, they can lead to dangerous complications for millions of people with asthma and chronic obstructive pulmonary disease.
Previous potential drugs for HRV either didn't work or caused unacceptable side effects, leaving only one potential drug still under development in clinical trials.
MacLeod's team set out to find new antiviral candidates to meet this serious health challenge.
They describe identifying and successfully testing a group of compounds that work against human rhinovirus, Coxsackie virus, poliovirus and enterovirus-71 - the cause of hand, foot and mouth disease.
The substances work by blocking the ability of these viruses to multiply.
The study is published in the journal ACS Medicinal Chemistry Letters.
