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Prenatal alcohol exposure during early stages of pregnancy lethal for baby

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ANI Washington

Animal experiments have shown that prenatal alcohol exposure in utero, especially during the early stages of pregnancy, can cause fetal alcohol syndrome.

The pharmacological and toxicological mechanisms of ethanol are considered to be related to the effects of ceramide.

As an important signal transduction molecule, ceramide participates in a variety of cellular transduction pathways and can modulate cell cycle, cellular differentiation, proliferation, and apoptosis.

A recent study verified that ceramide is involved in alcohol-induced neural proliferation in the hippocampal dentate gyrus of pups after prenatal ethanol exposure, and the mechanism may be associated with increased ex-pression of protein kinase C activating the ceramide/ceramide-1-phosphate pathway.

 

The study is published in the Neural Regeneration Research.

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First Published: Sep 16 2013 | 10:04 AM IST

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