Researchers have found that Probiotics do not help infants with colic.
Researchers based in Australia and Canada set out to determine whether the probiotic Lactobacillus reuteri reduces crying or fussing in 167 breastfed and formula fed infants with colic aged less than three months old.
A total of 85 infants were randomised to receive the probiotic and 82 to receive placebo for one month. Outcomes included daily duration of crying or fussing at one month, sleep duration, mother's mental health, family and infant quality of life.
Levels of gut microbial diversity, faecal calprotectin (a marker of gut inflammation) and E coli colonisation were also examined.
The results show that the probiotic group fussed significantly more than the placebo group at all time points from day seven to one month. At one month, the probiotic group cried or fussed 49 minutes more than the placebo group. This increased fussing occurred only in formula fed infants. L reuteri did not affect crying or fussing time in exclusively breastfed infants.
L reuteri treatment did not lead to changes in infant faecal microbial diversity, E coli colonisation, or calprotectin levels.
