A new study has found that activating a protein called sirtuin 1 extends lifespan, delays the onset of age-related metabolic diseases, and improves general health in mice.
The study points to a potentially promising strategy for improving health and longevity.
Sirtuin 1, or SIRT1, is known to play an important role in maintaining metabolic balance in multiple tissues, and studies in various organisms have shown that activating the protein can lead to many health benefits.
Also, drugs that increase SIRT1 activity have been found to slow the onset of aging and delay age-associated diseases in several animal models.
Researchers led by Dr. Rafael de Cabo of the National Institute on Aging at the National Institutes of Health tested the effects of a small molecule that activates SIRT1, called SIRT1720, on the health and lifespan of mice.
The researchers found that SRT1720 significantly extended the average lifespan of mice by 8.8 percent.
Supplementation also reduced body weight and body fat percentage, and it improved muscle function and motor coordination throughout the animals' lives.
The investigators found that SRT1720 supplementation led to decreases in total cholesterol and LDL-cholesterol levels, which might help protect against heart disease, and improvements in insulin sensitivity, which could help prevent diabetes.
Supplementation also had anti-inflammatory effects in various tissues, an important finding because low-grade chronic inflammation is thought to contribute to aging and age-related diseases.
The study is published in the journal Cell Reports.
