Study shows success of measles vaccine campaigns in India

A new report now says that a mass measles vaccination campaign saved thousands of children's lives in India between 2010 and 2013. The study was published today in eLife.

According to the study, the findings suggest that eliminating deaths from measles in India could be possible, although it will require continued diligence to ensure high immunisation rates among Indian children and direct mortality monitoring.

The results may also help to encourage greater uptake of vaccinations in children across the world.

There have been substantial decreases in the number of deaths from measles over the last 30 years. However, the infection remains a significant cause of mortality in children under five years old globally, with much of the burden of mortality and transmission residing in Africa and Asia.

 

India was one of the last countries to adopt two doses of the measles vaccine as part of national immunisation programs. In 2010, its government implemented second-dose measles vaccines alongside mass immunisation campaigns in districts (small administrative areas, each comprising about two million people) with low child vaccination rates.

Speaking about it study author Benjamin Wong said, "We know that measles deaths have declined in India, but what we did not know prior to this study is if the national measles campaign reduced child mortality rates," added, "Until now, no studies had directly answered this question due to gaps in the available data."

Wong and his team applied a novel statistical method to data from the Million Death Study (MDS) - a nationally representative sample of all deaths in India, which includes detailed interviews with families about child deaths.

They examined 27,000 child deaths from 1.3 million households surveyed from 2005 to 2013. During this period, the MDS captured deaths for 13,490 girls and 13,007 boys aged between one and 59 months old.

The current analysis suggests that the measles vaccine campaigns saved 41,000 to 56,000 children in India during 2010 to 2013, or 39 per cent-57 per cent of the expected number of deaths nationally. Mortality in children aged between one and 59 months fell more in the campaign states following launch (27 per cent) than in the non-campaign states (11 per cent). Measles mortality risk was notably lower for children living in the campaign districts and those born between 2010-2013.

The team also found that the campaign was particularly successful for girls, as there was a steeper decline in the mortality rates of girls than boys in the vaccination campaign states during the three-year period. But while this highlights a narrower gap between girls and boys, mortality rates remain higher for girls. This is possibly due to lower vaccination coverage, a social preference for boys and/or lower levels of breastfeeding and healthcare access.

Speaking about the study, senior author Prabhat Jha said, "Together, our results demonstrate the significant success of the measles vaccination campaigns in saving children's lives in India," adding, "We've shown that nationwide mortality studies that are representative of the population are an inexpensive and practical way to directly investigate the impact of interventions for other diseases in India and elsewhere.