Coach Leonardo Jardim's nightmare continued as Monaco suffered a 1-2 defeat to Lyon in the French Ligue 1 fifth-round matchup.
The last season's runners-up scored an equaliser through 20-year-old Argentine forward Lucas Ocampos on 36 minutes, just six minutes after Nabil Fekir opened scoring for the hosts on the half-hour mark at Stade de Gerland Friday night, reports Xinhua.
Corentin Tolisso, however, sealed the three points for Lyon in the 73rd minute with a creative team effort.
With the away defeat, Monaco, who saw star striker Radamel Falcao leave for Manchester United on loan on transfer deadline day, have just four points from five fixtures under new coach Jardim, wandering just two positions above the relegation zone.
And for their Lyon counterparts, Friday's victory saved them from three straight defeats after victory in the opener.